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KMID : 0378019890320010116
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New Medical Journal
1989 Volume.32 No. 1 p.116 ~ p.122
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A Clinical Trial of Fluoxetin
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Kim Jong-Ju
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Abstract
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Fluoxetine 20 mg was orally given once in the morning for 8. weeks to 30 patients with either dysthymic disorder or major depressive disorder. The total score as well as the scores of the most items of Hamilton Depression scale was significantly reduced after fluoxetine treatment. The response rate was 63.3%. Its sedative hypnotic effect was weak. Improvement was gradual and 50% decrease in global improvement scales reached in 4th week. No significant change was observed in vital signs and laboratory test including liver function test after 8 week treatment. Side effects such as loss of appetite, nausea, and weight loss were reported by some patients, but the incidence of anticholinergic side effect was very low.
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